منابع مشابه
Delicate Decisions
The anti-apoptotic BCL2-family member MCL1 can be induced by a number of growth factors and promote cell survival. However, how growth factors maintain MCL1 levels to prevent apoptosis has been unclear. Maurer et al. now report that the control of MCL1 stability by glycogen synthase kinase-3 (GSK3) is an important mechanism for the regulation of apoptosis by growth factors and AKT/protein kinas...
متن کاملA delicate balance
The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.
متن کاملA Delicate Universe
We investigate whether explicit models of warped D-brane inflation are possible in string compactifications. To this end, we study the potential for D3-brane motion in a warped conifold that includes holomorphically-embedded D7-branes involved in moduli stabilization. The presence of the D7-branes significantly modifies the inflaton potential. We construct an example based on a very simple and ...
متن کاملA Delicate Balance
The Accreditation Council for Graduate Medical Education (ACGME) recognized the importance of housestaff in the provision of hospital care when it regulated housestaff duty hours to improve patient safety. ACGME intended to create a better balance between the management of resident fatigue and the continuity of patient care, but the shorter hours mandated by duty hour reform have created more f...
متن کاملThe delicate bistability of CaMKII.
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a synaptic, autophosphorylating kinase that is essential for learning and memory. Previous models have suggested that CaMKII functions as a bistable switch that could be the molecular correlate of long-term memory, but experiments have failed to validate these predictions. These models involved significant approximations to overcome the...
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ژورنال
عنوان ژورنال: Academic Medicine
سال: 2019
ISSN: 1040-2446
DOI: 10.1097/acm.0000000000002513